Liver aetiological screen

A Liver Aetiological Screen investigates the cause for underlying liver disease, including:

  • Viral hepatitis (if the blood test abnormality is chronic this should include hepatitis b and c, if the blood test abnormality is acute this should include hepatitis a and e)
  • Autoimmune liver disease (measurements of AMA, SMA and ANA, as well as serum immunoglobulins)
  • Haemochromatosis (measurement of serum ferritin and transferrin saturation)
  • Alpha-1 antitrypsin deficiency (measurement of alpha-1 antitrypsin)
  • Wilson’s disease (measurement of caeruloplasmin)


A liver ultrasound scan, while not part of a liver aetiological screen, should be performed at this stage as an important part of the diagnostic work-up to look for features of advanced liver disease such as splenomegaly.

Mark as Understood

© Institute of Clinical Science and Technology (ICST) 2020